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Progress in Chemistry 2008, Vol. 20 Issue (06): 951-956 Previous Articles   Next Articles

• Review •

Correlation Between Molecular Structure, Electric Property and Biological Activity of Protein

Guo Yan1 Gao Xiaoling2 Zhao Jianwei1** Tian Yanni2

  

  1. (1. Key laboratory of Analytical Chemistry for Life Science (Education Ministry of China), College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210008, China; 2. Institute of Molecular Science, Shanxi University, Taiyuan 030006, China)
  • Received: Revised: Online: Published:
  • Contact: Jianwei Zhao
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In biological processes, many proteins are located in biomembrane, performing their biological activity, from respiration to energy conversion in vivo. As a result, the basic existing and functional form of protein is the one that can bear anisotropic stress. To devise and study the structure, mechanical and electrical/electrochemical properties of protein under anisotropic stress not only play an important role in understanding their bioactivity, but can promote application of proteins in bioelectronic devices. The studies on protein electric properties by using a conducting atomic force microscope have been reviewed. Under various anisotropic compressions, the protein molecular was subjected to different reconstructions, showing different electronic transportation behavior. On basis of the experimental observation, one can estimate the biological activity of the protein molecule.

Key words: proteins, electron transfer, QSAR, conducting atomic force microscope, bioelectrochemistry

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[ 1 ] Page C C , Moser C C , Chen X X, Dutton P L. Nature , 1999 ,402 : 47 —52
[ 2 ] Reinerth W A , Jones L , Burgin T P , Zhou C W, Muller C J ,Deshpande M R , Reed M A , Tour J M. Nanotechnology , 1998 ,9 : 246 —250
[ 3 ] Holmlin R E , Haag R , Chabinyc M L , Magilov R F , Cohen A E ,Terfort A , Rampi M A , Whitesides G M. J . Am. Chem. Soc. ,2001 , 123 : 5075 —5085
[ 4 ] Kushmerick J G, Holt D B , Pollack S K, Ratner MA , Yang J C ,Schull TL , Naciri J , Moore M H , Shashidhar R. J . Am. Chem.Soc. , 2002 , 124 : 10654 —10655
[ 5 ] Sikes H D , Smalley J F , Dudek S P , Cook A R , Newton M D ,Chidsey C E D , Feldberg SW. Science , 2001 , 291 : 1519 —1523
[ 6 ] Pascher T , Chesick J P , Winkler J R , Gray HB. Science , 1996 ,271 : 1558 —1560
[ 7 ] Amstrong F A , Hill H A O , Walton N J . Acc. Chem. Res. ,1988 , 21 : 407 —413
[ 8 ] 董绍俊(Dong S J ) , 车广礼(Che G L) , 谢远武(Xie Y W) .化学修饰电极( 修订版) ( Chemically Modified Electrode )(2nd) . 北京: 科学出版社(Beijing : Science Press) , 2003
[ 9 ] Bendall D S. Protein Electron Transfer. Oxford : BIOS Scientific Publishers Ltd , 1996
[10] Bonanni B , Andolfi L , Bizzarri A R , Cannistraro S. J . Phys.Chem. B , 2007 , 111 : 5062 —5075
[11] Zhao J , Uosaki K. Langmuir , 2001 , 17 : 7784 —7788
[12] Zhao J , Uosaki K. Nano Lett . , 2002 , 2 : 137 —140
[13] Adman E T. Adv. Protein Chem. , 1991 , 42 : 145 —197
[14] Chi Q , Zhang J , Nielsen J U , Friis E P , Chorkendorff I , Canters G W, Andersen J E T , Ulstrup J . J . Am. Chem. Soc. , 2000 ,122 : 4047 —4055
[15] Zhao J , Davis J J , Sansom M S P , Hung A. J . Am. Chem.Soc. , 2004 , 126 : 5601 —5609
[16] Zhao J , Davis J J . Colloid Surf . B , 2005 , 40 : 189 —194
[17] 赵健伟(Zhao J W) , 王楠(Wang N) . 高等学校化学学报(Chem. J . Chinese University) , 2005 , 26 : 751 —753
[18] Zhao J W, Uosaki K. Appl . Phys. Lett . , 2003 , 83 : 2034 —2036
[19] Luo E Z , Lin S , Xie Z , Xu J B , Wilson I H , Yu Y H , Yu L J ,Wang X. Mater. Charact . , 2002 , 48 : 205 —210
[20] Davis J J , Wang N , Morgan A , Zhang T , Zhao J . Faraday Discussions , 2005 , 131 : 167 —179
[21] Gorman C B , Carroll R L , Fuierer R R. Langmuir , 2001 , 17 :6923 —6930
[22] Fan F R F , Lai R Y, Cornil J , Karzazi Y, Bredas J L , Cai L ,Cheng L , Yao Y, Price D WJr , Dirk S M, Tour J M, Bard AJ .J . Am. Chem. Soc. , 2004 , 126 : 2568 —2573
[23] Sutin N , Brunschwig B S , Creutz C. J . Phys. Chem. B , 2003 ,107 : 10687 —10690
[24] Davis J J , Morgan D A , Wrathmell C L , Axford D N , Zhao J ,Wang N. J . Mater. Chem. , 2005 , 15 : 2160 —2174
[25] Zhao J , Davis J J . Nanotechnology , 2003 , 14 : 1023 —1028
[26] Simmons J G. J . Appl . Phys. , 1963 , 34 : 1793 —1803
[27] Tian WD , Datta S , Hong S H , Reifenberger R , Henderson J I ,Kubiak C P. J . Chem. Phys. , 1998 , 109 : 2874 —2882
[28] 赵健伟(Zhao J W) , 史传国(Shi C G) , 周毅(Zhou Y) , 陈洪渊(Chen H Y) . 分析化学(Chin. J . Anal . Chem. ) , 2005 ,33 : 1494 —1498
[29] Zhao J , Uosaki K. J . Phys. Chem. B , 2004 , 108 : 17129 —17135
[30] Sarkar A , Robertson R B , Fernandez J M. Proc. Natl . Acad.Sci . USA , 2004 , 101 : 12882 —12886
[31] Bao G. J . Mech. Phys. Solids , 2002 , 50 : 2237 —2274
[32] Clausen2Schaumann H , Seitz M, Krautbauer R , Gaub H E. Curr.Opin. Chem. Biol . , 2000 , 4 : 524 —530
[33] Axford D , Davis J J , Wang N , Wang D , Zhang T , Zhao J , Peters B. J . Phys. Chem. B , 2007 , 111 : 9062 —9068
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