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Progress in Chemistry 2008, Vol. 20 Issue (06): 936-941 Previous Articles   Next Articles

• Review •

Stimuli-responsive Non-viral Gene Delivery Vectors

Ji Weihang; Lin Lin; Chen Dayong; Liu Wenguang**

  

  1. (School of Materials Science and Engineering, Tianjin 300072, China)
  • Received: Revised: Online: Published:
  • Contact: Liu Wenguang
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Polycations are able to form stable polyelectroylte complexes (PECs) with DNA via strong electrostatic interaction. The PECs are favorable for an efficient DNA condensation to facilitate cell internalization, endolysosomal escape and protect DNA from DNase attacking. However, tight compaction of DNA in complexes tends to prevent its release from its carrier, deteriorating the ultimate gene expression. In light of this demerit inherent to PECs, a new type of smart or intelligent polymer vectors have been designed. These smart polymers are capable of responding to microenviromental changes, such as temperature, pH and the redox by varying macromolecular conformation, which aids in unpacking DNA from complex, consequently increasing transfection efficiency. This article presents the recent progress in poly(N-isopropylacrylamide)-based temperature, light, intracellular pH and glutathione responsive non-viral vectors.
Key words: stimuli-responsive, non-viral vectors, polycations

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