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Progress in Chemistry 2008, Vol. 20 Issue (06): 899-908 Previous Articles   Next Articles

• Review •

Ionic Liquid Supported Substrates for Organic Synthesis

Lai Jingjuan1 Zhou Jianhua2 Zheng Mingang1 Longquan1 Zheng Baozhong1*   

  1. (1. Department of Materials Science and Engineering, Yunnan University, Kunming 650091, China;
    2. Institute of Modern Physics, Northwest University, Xi’an 710069, China)
  • Received: Revised: Online: Published:
  • Contact: Zheng Baozhong
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The new concept of the soluble ionic liquid supported organic synthesis in the solid and liquid-phase combinatorial chemistry and the recent progress are described. The paper mainly describe the use of the ionic liquid supported substrates for organic synthesis in the relational important organic reactions, combinatorial chemistry and the synthesis of the small molecules library. The ionic liquid supported substrates strategy has many advantages, such as the higher loading capacity, the routine product isolation by simple extraction and washings, the structure could be verified easily by routine spectroscopic methods at each step, the recovered supports after cleavage can be reused in another cycle without losing its activities. All of these are significant changes for the traditional solid and liquid-phase synthesis.
Key words: ionic liquid support, supported substrates, solid-phase organic synthesis, liquid-phase organic synthesis, combinatorial chemistry, small molecule library

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