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Progress in Chemistry 2008, Vol. 20 Issue (06): 869-877 Previous Articles   Next Articles

• Review •

Advances in the Serotonin Transporter Imaging Agents

Guo Yunxing; Liu Boli**

  

  1. (Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China)
  • Received: Revised: Online: Published:
  • Contact: Boli Liu
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Alterations of serotonergic neuronal function, particularly changes of density in the presynaptically located serotonin transporter (SERT) occur in psychiatric disorders. Imaging of SERT with positron emission tomography (PET) and single photon emission computed tomography (SPECT) in humans can provide an important tool for understanding the relationship of psychiatric disorders and the alterations in SERT density, as well as to monitor the treatment of patients. This review discusses the recent development of SERT imaging agents and the research trends for the future.

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