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Progress in Chemistry 2008, Vol. 20 Issue (05): 747-753 Previous Articles   Next Articles

• Review •

Monolithic Column for High Performance Liquid Chromatography

Li Zhenying; Duan Hongquan; Huang Yanping; Liu Zhaosheng**   

  1. (College of Pharmacy, Tianjin Medical University, Tianjin 300070, China)
  • Received: Revised: Online: Published:
  • Contact: Liu Zhaosheng
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Molecular imprinting is a new approach to prepare predictable selectivity stationary and monolithic collumn is a novel technology for chromatographic stationary phase. The combination of monolith and molecularly imprinted polymers(MIPs) integrates the high efficiency of liquid chromatography and the high selectivity of MIPs, which will accelerates the develpoment of MIPs technique in the field of separation science. Therefore, the research in this field has attracted considerable interests and plays an important role in the area of analytical chemistry. In this review，the progress of molecularly imprinted monolith is summarized in detail from the polymerization conditionsto prepare MIPs' physical monolith, the separation conditions to evaluate the efficiency of MIPs, and the method of characterizingg MIPs' physical and chemical properties concerning the application of liquid chromatography-based MIPs. The limitations and prospective applications of the technique relates with MIPs monolithic column are also discussed．
Key words: molecularly imprinted polymers, monolithic columns, liquid chromatography, in-situ polymerization

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