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Progress in Chemistry 2008, Vol. 20 Issue (05): 729-739 Previous Articles   Next Articles

• Review •

Preparation of NO releasing Polymers and Their Applications for Biomedical Devices

Kou Yuxia; Wan Ajun**   

  1. (Department of Chemistry, School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China)
  • Received: Revised: Online: Published:
  • Contact: Wan Ajun
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Nitric oxide(NO) is a potent inhibitor of platelet adhesion and activation, and an excellent inhibitor of smooth muscle cell proliferation. NO releasing polymers exhibited enhanced thromboresistivity and had the potential to reduce neointimal hyperplasia. In this artical, the recent studies on the preparation, characterization and biomedical applications of novel NO releasing polymeric materials are reviewed. N-diazeniumdiolates and S-nitrosothiols (RSNOs) are two main types of NO donors which used to prepare NO releasing polymers. The approaches taken to prepare NO releasing polymers are classified into three catogories: (1)doping discrete NO nonors within polymer matrix; (2)covalent attachment of NO resealing moieties on the filler particles of the polymer to provide NO releasing properties and then dispersion them into the polymer backbone; (3) covalent linkage of NO donors to polymer molecules. The various NO releasing polymers have potential applications in biomedical devices, such as intravascular sensors, extracorporeal bloodloop circuits, and arteriovenous grafts etc.
Key words: nitric oxide(NO), N-diazeniumdiolates, NO releasing polymers, biomedical devices

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