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Progress in Chemistry 2008, Vol. 20 Issue (04): 594-601 Previous Articles   Next Articles

• Review •

Desorption Electrospray Ionization

Xue Zhen; Qiu Bo; Lin Guangxin; Lai Congfang; Luo Hai**   

  1. (Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China)
  • Received: Revised: Online: Published:
  • Contact: Luo Hai
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Desorption electrospray ionization (DESI), a new ionization method of mass spectrometry, and its most recent research advances were reviewed. This method was first introduced in 2004 and developed very rapidly because of its advantageous analytical characteristics, such as ambient working conditions, without sample preparation, and capable of directly analyzing solid or condensed form of samples from a variety of substrate surfaces. The comprehensive recent studies of DESI are reviewed in several aspects, including its basic principle, ion source structure, the optimal operational parameters and the substrate surfaces used in the ionization process. This article also summarizes applications of DESI technique in monitoring ambient gas-phase chemical reaction products, characterizing synthetic polymers, detecting explosives and chemical warfare agents, analyzing drugs and metabolites, and profiling biological tissue surfaces. Meanwhile, the future directions of fundamental and applied research using DESI technique are commented.

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Abstract

Desorption Electrospray Ionization