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Progress in Chemistry 2008, Vol. 20 Issue (04): 429-440   Next Articles

• Review •

High-throughput Natural Product Chemistry Methods and the Application of the Capillary NMR Probe

Hu Jinfeng1,2**; Gary R.Eldridge1;Yu Yihua3;Mark O's Neil-Johnson2

  

  1. (1. Key Laboratory of Brain Functional Genomics of the Ministry of Education, East China Normal University, Shanghai 200062, China; 2. Sequoia Sciences, Inc., Saint Louis, Missouri 63114, USA; 3. Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai 200062, China)
  • Received: Revised: Online: Published:
  • Contact: Hu Jinfeng
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High-throughput natural product chemistry methods, mainly consisting of two parallel multi-channel systems of preparative HPLC and LC-ELSD-MS, have been applied to the generation and analysis of large natural product libraries. The enhancement on mass sensitivity by the low volume capillary NMR probe (CapNMRTM) technology makes the NMR data acquisition, structure elucidation and de-replication on microgram amounts of natural products a reality. This state-of-the-art probe has ushered in a new era in the miniaturization of structure elucidation of natural products using mass-limited material. The perspectives for natural products as small molecular probes in brain functional genomics are briefly provided.
Key words: high-throughput natural product chemistry methods, natural product libraries, CapNMRTM probe, miniaturization of the structure elucidation process, chemical genomics

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