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Progress in Chemistry 2008, Vol. 20 Issue (01): 60-75 Previous Articles   Next Articles

• Review •

Application of Microfluidic Reactors on Synthesis Reactions

Mu Jinxia; Yin Xuefeng*   

  1. （Department of Chemistry, Zhejiang University, Hangzhou, 310027, China）
  • Received: Revised: Online: Published:
  • Contact: Yin Xuefeng
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Microfluidics is the technology that processes or manipulates small (10–9 to 10–18 litres) amounts of fluids using channels with dimensions of tens to hundreds of micrometres. Microfluidic reactors have a number of advantages over conventional chemical laboratory batch methodologies, such as short molecular diffusion distance, large specific surface area, high mass and heat transfer capacity, which will be expected to promote highly effective chemical reactions in the microfluidic reactor. The main features of microfluidic reactors, the method to drive liquid through the microchannels and the method for mixing liquids in microchennels are summarized in this review. Subsequently, the effects of downscaling reaction vessels as well as the advantages of the continuous flow microfluidic approach are illustrated by a number of examples of organic reactions carried out in microfluidic devices, including liquid- liquid miscible fluid reaction, catalytic reaction, phase transfer reaction and strongly exothermic or endothermic organic synthesis. The development of microfludic reactors is not only of great significance for optimizing many synthetic procedures, but also helpful for improving related chemical industry processes.
Key words: microfluidic reactors, mixing, organic synthesis, microfludics manipulation

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