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Progress in Chemistry 2007, Vol. 19 Issue (10): 1529-1536 Previous Articles   Next Articles

• Review •

The Dearomatizetion of Aromatic Compounds

Shirong Lu;Bo Peng;Ming Bao**   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012,China
  • Received: Revised: Online: Published:
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Dearomatization reactions of arenes have been attracted considerable interest because they allow the use of stable and widely available materials to provide functionalized alicyclic compounds, which could be em-ployed as synthetic building blocks for synthesis of natural products and bioactive compounds. Over the past four decades, many dearomatization reactions have developed and applied for synthesis of alicyclic compounds con-taining six–membered carboncyclic moieties. This article reviews six kinds of dearomatization reactions of aro-matic compounds including oxidative dearomatization, reductive dearomatization, photocatalyzed dearomatization, nucleophilic additive dearomatization, σ-rearrangement dearomatization, transition metals promoted dearomatiza-tion, are reviewed. Among them, the transition metals promoted dearomatization proceeded under mild reaction conditions with various substrates, and which could be applied for synthesis of bioactive compounds.
Key words: dearomatization, oxidation, reduction, photocatalysis, rearrangement, transition metals

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Abstract

The Dearomatizetion of Aromatic Compounds