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Progress in Chemistry 2007, Vol. 19 Issue (0708): 1159-1163 Previous Articles   Next Articles

• Special issues •

Systematic Analysis of Yeast Response to Inhibitors

Xia Jinmei;Lin Fengming;Yuan Yingjin**   

  1. School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China
  • Received: Revised: Online: Published:
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It is widely known that the presence of multiple inhibitors produced during the biomass-to-ethanol process has obvious inhibitory effects to yeast. In fact, the inhibition effect of the hydrolysis-accompanying small molecules is one of the several big obstacles retarding the development of biomass-to-ethanol process. Scientists have made a lot of efforts in conquering this problem. Many facts have been found. It is noticed that, with the presence of inhibitors, yeast has corresponding changes on all three levels: genome, proteomel and metabolome level. What is more, the changes on different levels are correlative. The complexity of investigating the comprehensive response of yeast to inhibitors calls for the application of system methodology. With its high-throughput analyzing technologies and bioinformatics tools, system level analysis is promising in finally solving the bewildering problem. In this paper, the notion and approaches of system methodology in figuring out the mechanism of the inhibitors tolerance of yeast are reviewed; the main research techniques and progresses are summarized; the prospect of systems methodology in studying the inhibitors-tolerance of yeast is discussed.
Key words: yeast, inhibitors, system level analysis

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