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Progress in Chemistry 2007, Vol. 19 Issue (05): 713-721 Previous Articles   Next Articles

• Review •

σ- Receptor Ligands as Imaging Agents

Zhang Qiuyan;Fan Caiyun;Jia Hongmei**   

  1. Key Laboratory of Radiopharmaceuticals , Ministry of Education,College of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received: Revised: Online: Published:
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Sigma (σ) receptors have been proposed to be involved in cellular functions, biological processes and diseased. Sigma-1 receptors have recently been a novel target of drug development related to CNS disorders such as schizophrenia, depression, Alzheimer, and Parkinson diseases, while sigma-2 receptors are regarded as a biomarker of tumor proliferation.Sigma-1 receptor imaging agents can provide a powerful diagnostic tool to fight with neuropsychiatric diseases of human beings, while sigma-2 receptors imaging agents are the sensitive molecular probes for the early diagnosis of malignant tumor. This review provides the overview of recent advance of sigma receptors imaging agents. The emphases are focused on design methods of different sigma receptor imaging agents based on their possible applications. The trend for development of σ receptor imaging agents has also been discussed.
Key words: σ receptor, imaging agents, tumor, central nervous system (CNS)

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Abstract

σ- Receptor Ligands as Imaging Agents