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Progress in Chemistry 2007, Vol. 19 Issue (0203): 420-430 Previous Articles   Next Articles

• Review •

Advances in Influenza Virus Sialidase Inhibitors

Niu Youhong1,2; Cao Xiaoping1; Ye Xinshan2**   

  1. 1.State Key Laboratory of Applied Organic Chemistry, Lanzhou University, LanZhou 730000,China;

    2.State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083,China

  • Received: Revised: Online: Published:
  • Contact: Ye Xinshan
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Due to the recent emergence of avian flu, the possibility of a pandemic wave of life-threatening flu is a serious worldwide concern. Tamiflu, one of the outstanding successes of rational drug design, becomes a star drug that inhibits virus sialidase (neuraminidase), an enzyme crucial for the release and spread of the influenza virus form infected cells. This event stimulated many people to seek a share of the potentially huge flu drug market. On the basis of a brief introduction of sialidases and their functions, this review summarizes the recent advances in influenza virus sialidase inhibitors with particular focus on the transition state-based design, the synthetic scaffold types of carbohydrate mimetics, and the structure-activity relationship of structure-based sialidase inhibitors. Since sialidases are involved in the pathogenesis of a wide range of other diseases, the knowledge and expertise gained from the influenza study could be used in the design of other drugs, given that they all share certain structural features.
Key words: sialidase inhibitors, zanamivir, antivirus, avian flu

CLC Number: 

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