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Progress in Chemistry 2007, Vol. 19 Issue (0203): 385-392 Previous Articles   Next Articles

• Review •

New Development and Applications in Time-of-Flight Mass Spectrometer

Hou Keyong1,2; Dong Can1,2; Wang Junde1;Li Haiyang1*   

  1. 1.Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023，China;

    2.Graduate School,Chinese Academy of Sciences,Beijng 100039,China

  • Received: Revised: Online: Published:
  • Contact: Li Haiyang
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The new developed soft ionization sources which is used in time-of-flight mass spectrometer is introduced. Proton-Transfer-Reaction(PTR) ionization is a high sensitive method for volatile organic compound. Vacuum ultraviolet lamp ionization source is attractive for portable analytical instrument because of its smallness and simpleness. Desorption electrospray ionization provide better solution for real-time, on-line and high sensitive analysis of volatile and semi-volatile organic compounds. Furthermore, it can be used in vivo sampling or living tissue surface. Atmospheric pressure direct analysis in real time ionization uses electric excited states of atoms or molecules of carrier gas to produce molecular ions for analysis. Applications of these new ionization methods to various problems are also discussed. The progress in hybrid TOF instruments and miniaturizing instruments is reviewed and perspectives for the development of TOF-MS instrument are provided.
Key words: time of flight mass spectrometer(TOF-MS), soft ionization, hybrid TOF-MS instruments, miniaturizing TOF-MS

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