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Progress in Chemistry 2007, Vol. 19 Issue (0203): 201-204   Next Articles

• Review •

Trends and Problems in Studies of Rare-Earths-Based Drugs

Yang Xiaogai; Yang Xiaoda; Wang Kui**   

  1. Department of Chemical Biology ,School of Pharmaceutical Sciences, Peking University Health Sciences Center, Bejing 100083, China
  • Received: Revised: Online: Published:
  • Contact: Wang Kui
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The interest on the studies of rare-earths-based drugs is increasing.The recent issue of Chemical Society Reviews is a special issue devoting to the current studies in this aspect. In the present comment, the trends and problems are discussed in connection with the current status in this field and the reviews published in the Chemical Society Reviews. The basic problems open for clarification are emphasized. Enlightened by the changing research paradigm for drug exploration, the following working principles are discussed: to convert the adverse biological effects to the pharmacological ones, to lay the basis of study on the intervention on cell signalling networks, to handle the activity-toxicity relationship and the strategies for rational design.
Key words: rare earths, biological effects, therapeutic agents

CLC Number: 

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