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Progress in Chemistry 2007, Vol. 19 Issue (01): 165-172 Previous Articles   Next Articles

• Review •

Application of Raman Spectra in Solid-Phase Organic Synthesis

Huang Qiang**;Long Quan;Zheng Baozhong   

  1. Department of Materials Science and Engineering, Yunnan University, kunming 650091, China
  • Received: Revised: Online: Published:
  • Contact: Huang Qiang
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The recent application of Raman spectroscopy in solid- phase organic synthesis is reviewed.Two Raman spectra of NIR-FT-Raman spectroscopy and Confocal Raman microscopy are introduced respectively. NIR-FT-Raman spectroscopy could be used for the characterization of solid-supported reagents and catalysts, for monitoring of solid-phase reactions, and especially for monitoring the solid-phase reactions on inorganic supports since the interference of fluorescence emission background could be removed by this technique. Confocal Raman microscopy was used to study the distribution of reactive sites within a resin bead and character the structure of grafted supports used for solid-phase synthesis taking the advantage of high spatial resolution.
Key words: Combinatorial Chemistry, Solid-Phase Organic Synthesis(SPOS), NIR-FT-Raman Spectra, Confocal Raman microscopy

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