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Progress in Chemistry 2006, Vol. 18 Issue (11): 1440-1445 Previous Articles   Next Articles

• Review •

The Interaction between DNA and Amphoteric Surfactants

Yanqing Sun1;Jian Zhang2;Gaoyong Zhang1**;Hongxia Wang1   

  1. 1. State Center for Surfactant Research and Engineering, China Research Institute of Daily Chemical Industry, Taiyuan 030001, China;2. Key Laboratory of Coal Science and Technology, Ministry of Education and Shanxi Province, Taiyuan University of Technology, Taiyuan 030032, China
  • Received: Revised: Online: Published:
  • Contact: Yanqing Sun
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The Research Progress of interaction between DNA and amphoteric surfactant is reviewed. Relevant studying methods of interaction-observering and complex-charactering, such as fluorescent microscopic technology, light scattering, phase diagram and turbidimetric titration are expatiated. Owing to the characteristic of amphoteric surfactant, in specific range of pH it could induce discrete conformational transition of DNA from unfolded coil to compacted globule by electrostatic attraction. Interaction between DNA and amphoteric surfactant is controlled by pH and ion strength. The DNA-amphoteric surfactant complexes have potential application as gene vectors.

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