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Progress in Chemistry 2006, Vol. 18 Issue (10): 1381-1390 Previous Articles   Next Articles

• Review •

Hydroxyl Polycyclic Aromatic Hydrocarbons in Human Urine as Biomarkers of Exposure to PAHs

Hongyun Niu1;Yaqi Cai1*;Fusheng Wei1,2*;Shifen Mou1;Guibin Jiang1   

  1. 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China; 2. China National Environmental Monitoring Center, Beijing 100029, China
  • Received: Revised: Online: Published:
  • Contact: Yaqi Cai;Fusheng Wei
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Polycyclic aromatic hydrocarbons which are typical persistent organic pollutants may induce lung and skin cancers in occupational settings. And the evaluation of the exposure to PAHs can provide useful data for epidemiological study and risk assessment of the pollutants. However , due to the complexity of exposure , urinary hydroxyl PAHs which are major metabolites of PAHs in human urine have been widely used as biomarkers of internal dose to evaluate the exposure to PAHs. The absorption , metabolism and the major forms of metabolites of PAHs in urine are reviewed in the paper. Furthermore several important biomarkers and factors that may cause the variation of metabolites excreted in urine are introduced.

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