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Progress in Chemistry 2006, Vol. 18 Issue (10): 1288-1297 Previous Articles   Next Articles

• Review •

Synthesis and Surface-Modifications of Iron Oxide Magnetic Nanoparticles and Applications on Separation and Analysis

Zilai Zhao;Zhengyun Bian;Langxing Chen**;Xiwen He;Yanfen Wang   

  1. Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received: Revised: Online: Published:
  • Contact: Langxing Chen
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Iron oxide magnetic nanoparticles with biocompatibility and functional coatings via appropriate surface chemistry approaches have been used for immobilization of cells ,proteins ,enzymes ,antibodies ,oligonucleotides and drugs through covalent bonding or adsorption. The surface-modified magnetic nanoparticles have been widely used in biological and biomedical areas such as immobilization of biomolecules ; separation of metal ions , cells , proteins , DNA ;immunoassay , biochemical analysis and magnetic resonance imaging (MRI) probes. In this paper , preparation methods ,surface modification approaches and analytical applications of iron oxide－based magnetic nanoparticles are reviewed.
Key words: iron oxide, magnetic nanoparticles, synthesis, surface modification, magnetic separation, biochemical analysis

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