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Progress in Chemistry 2006, Vol. 18 Issue (0708): 995-1001 Previous Articles   Next Articles

• Review •

Advances in 13C Metabolic Flux Analysis

Xiaojing Li;Tao Chen;Xun Chen;Xianggao Li;Xueming Zhao*   

  1. Deparment of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
  • Received: Revised: Online: Published:
  • Contact: Xueming Zhao
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Metabolic flux analysis(MFA) is a powerful tool on characterization of cellular state by quantification of intracellular fluxes in metabolic network. For overcoming the limitation of stoichiometric MFA, 13C MFA based on carbon-labeling experiments has been developed. In this paper, the principle and the method of 13C MFA are introduced, the development of 13C MFA in experiment and data analysis are summarized, and the important roles of MFA in the research of functional genomics are reviewed. The future developments of MFA are prospected.

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Advances in 13C Metabolic Flux Analysis