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Progress in Chemistry 2006, Vol. 18 Issue (0708): 966-973 Previous Articles   Next Articles

• Review •

Development of Multiphase Laminar Flow on Microfluidic Analysis

Ying Feng;Min Wang*   

  1. Institute of Microananlytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310028, China
  • Received: Revised: Online: Published:
  • Contact: Min Wang
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The phenomenon of laminar flow in micro-channel has drawn increasing attention since its first application for micro scale liquid-liquid extraction. Due to its simple fabrication process, easy and convenient handling, and powerful capability to pattern topographical structures on microchips, it has been developed into a fabrication and analysis method, opening up a new direction for microfluidic research. In this paper, the theory and recent development of multiphase laminar flow in microfluidics, particularly molecular diffusion, transfer and chemical reactions through the laminar flow interface, laminar flow etching for microchannels, and its applications in preparation of nano materials and bioanalysis are investigated and discussed. Examples are given, including fabrication of microfluidic chips with laminar flow, preparation of microreactors, separation and analysis of ions and molecules, formation and decoration of polymer membrane, organic synthesis in microchannels, control of solution concentrations for immunoassay, single cell analysis, micromolecule manipulation, and pretreatment of bioreagents.

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