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Progress in Chemistry 2006, Vol. 18 Issue (0708): 1056-1064 Previous Articles   

• Special issues •

Thermodynamic Studies on Mechanism of Chiral Resolution by Liquid Chromatography

Wen Weng1**;Bixia Yao1; Xiuqin Chen1; Youzun Chen1; Wenshi Lin1; Qingle Zeng2   

  1. 1.Department of Chemistry and Environmental Science, Zhangzhou Teachers College, Zhangzhou 363000, China; 2. Department of Chemistry, Xiamen University, Xiamen 361005, China
  • Received: Revised: Online: Published:
  • Contact: Wen Weng
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Chiral recognition is an important part of molecular recognition. Studies of mechanistic aspects of chiral resolution by liquid chromatography are helpful to optimize chromatographic conditions , to design novel chiral stationary phases and to understand chiral recognition mechanisms. In this paper , the methodologies for deriving corresponding thermodynamic parameters in the chiral resolution processes by linear or nonlinear chromatography are reviewed. The meaning of correlative parameters is explained. The applications of these parameters in the studies of mechanistic aspects of retentions and chiral resolutions by liquid chromatography are expatiated , and corresponding research prospects are put forward.
Key words: liquid chromatography, chiral resolution, chiral recognition, thermodynamic parameters

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