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Progress in Chemistry 2006, Vol. 18 Issue (0708): 1002-1008 Previous Articles   Next Articles

• Review •

Biopartitioning Chromatography: High Throughput Screening in Drug Membrane Permeability and Activity

Jin Sun;Yongjun Wang;Zhonggui He**   

  1. Deparment of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical  University, Shenyang 110016, China
  • Received: Revised: Online: Published:
  • Contact: Zhonggui He
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Biopartitioning chromatography (BPC) emulates drug-membrane interactions by introducing biomembrane-mimetic into chromatographic system, and has become a high throughput screening platform for evaluating drug membrane permeability and biological activity. The theoretical basis, classification and application of BPC are overviewed based on the latest advances and our recent works. The development potential and perspectives of BPC are also discussed.
Key words: biopartitioning chromatography, permeability, activity, high-throughput screening

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