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Progress in Chemistry 2006, Vol. 18 Issue (06): 841-848 Previous Articles   

• Special issues •

Thermodynamic Analysis of Mitochondria Working State

Sha Liu;Huixue Liu;Xiaogai Yang;Xiaoda Yang**   

  1. Department of Chemical Biology & Laboratories of Preventive Pharmaceutics, School of Pharmaceutical Sciences, Peking University Health Sciences Center, Beijing 100083, China
  • Received: Revised: Online: Published:
  • Contact: Xiaoda Yang
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Mitochondria, the “plant” of energy in cells, recently received great attention for its roles in metabolic diseases, e.g. diabetes and neural degenerative diseases. In this review, we briefly summarize the major recent progress in the biochemical and relevant studies of mitochondria and discuss comprehensively the working mechanisms and regulations of mitochondria, i.e. the chemiosmosis theory. A novel hypothesis of thermodynamic regulation of mitochondria function is proposed based on the reported results.

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