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Progress in Chemistry 2006, Vol. 18 Issue (05): 627-634 Previous Articles   Next Articles

• Review •

Advances in the Study of DNA Condensation in Vitro

Bingqi Zhang Wenguang Liu Cong Tang Weihang Ji Kangde Yao   

  1. Institute of Polymeric Materials, Tianjin University Institute of Polymeric Materials, Tianjin University Institute of Polymeric Materials, Tianjin University
  • Received: Revised: Online: Published:
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DNA condensation is a common physiological phenomenon in nature and also a key step in non-viral vector-mediated gene transfection. Understanding the characteristics of DNA condensation in vitro will aid in designing highly efficient non-viral vectors. In this article, the latest progress in the study of DNA condensation in vitro induced by multivalent cations is reviewed covering the mechanism, process, influencing factors of DNA condensation and its recent applications in gene transfection.

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