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Progress in Chemistry 2006, Vol. 18 Issue (0203): 344-348 Previous Articles   Next Articles

• Review •

Bioseparation and Bioanalysis Based on Magnetophoresis

Jinjing Che; Qianhong Wan**   

  1. College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China
  • Received: Revised: Online: Published:
  • Contact: Qianhong Wan
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Magnetically induced migration of particles in liquid, also known as magnetophoresis, is an effective approach for selective separation of bioparticles such as cells and large nucleic acids. The principle of magnetophoresis is introduced based on the balance between magnetic and drag forces acting on a magnetically responsible particles in liquid. Three magnetophoretic separation methods including magnetic split-flow thin fractionation, quadrupole magnetic flow sorting and on-chip free-flow fractionation are described with emphasis on device structure, operation principle and application in bioanalysis and bioseparation.
Key words: magnetophoresis, split-flow thin fractionation, quadrupole magnetic flow sorter, on-chip free-flow fractionation, bioseparatioin

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[ 1 ] Watarai H , Suwa M, Iiguni Y. Anal . Bioanal . Chem. , 2004 ,378 : 1693 —1699
[ 2 ] Fuh C B , Tsai H Y, Lai J Z. Anal . Chim. Acta , 2003 , 497 :115 —122
[ 3 ] Cunha F R , Sobral Y D. Physica A , 2004 , 343 : 36 —64
[ 4 ] Zborowski M, Ostera G R , Moore L R , et al . Biophys. J . ,2003 , 84 : 2638 —2645
[ 5 ] McCloskey K E , Chalmers J J , Zborowski M. Anal . Chem. ,2003 , 75 : 6868 —6874
[ 6 ] Hartig R , Hausmann M, Schmitt J , et al . Electrophoresis , 1992 ,13 : 674 —676
[ 7 ] Tchikov V , Schuetze S , Kroenke M. J . Magn. Magn. Mater. ,1999 , 194 : 242 —247
[ 8 ] Suwa M, Watarai H. Anal . Chem. , 2001 , 73 : 5214 —5219
[ 9 ] Zborowski M, Moore L R , Williams P S , et al . Sep. Sci .Technol . , 2002 , 37 : 3611 —3633
[10] Moore L R , Milliron S , Williams P S , et al . Anal . Chem. ,2004 , 76 : 3899 —3907
[11] Carpinoa F , Moorea L R , Zborowski M, et al . J . Magn. Magn.Mater. , 2005 , 293 : 546 —552
[12] Zhang Y, Emerson D R. J . Chromatogr. A , 2004 , 1042 : 137 —145
[13] Springson S R , Myers M N , Giddings J C. Anal . Chem. , 1987 ,59 : 344 —350
[14] Fuh C B , Myers M N , Giddings J C. Anal . Chem. , 1992 , 64 :3125 —3132
[15] Fuh C B , Chen S. J . Chromatogr. A , 1998 , 813 : 313 —324
[16] Zhang Y Z, Emerson D R , Reese J M. J . Chromatogr. A , 2003 ,1010 : 87 —94
[17] Fuh C B , Su Y S , Tai H Y. J . Chromatogr. A , 2004 , 1027 :289 —296
[18] Chalmers J J , Zhao Y, Nakamura M, et al . J . Magn. Magn.Mater. , 1999 , 194 : 231 —241
[19] Zborowski M, Sun L , Moore L R , et al . J . Magn. Magn.Mater. , 1999 , 194 : 224 —230
[20] Moore L R , Rodriguez A R , Williams P S , et al . J . Magn.Magn. Mater. , 2001 , 225 : 277 —284
[21] Zborowski M, Williams P S , Sun L , et al . J . Liq. Chromatogr.Relat . Technol . , 1997 , 20 : 2887 —2905
[22] Moore L R , Zborowski M, Nakamura M, et al . J . Biochem.Biophys. Methods , 2000 , 44 : 115 —130
[23] Chalmers J J , Haam S , Zhao Y, et al . Biotechnol . Bioeng. ,1999 , 64 : 509 —518
[24] Chalmers J J , Haam S , Zhao Y, et al . Biotechnol . Bioeng. ,1999 , 64 : 519 —526
[25] Hafelia U O , Lobedannb M A , Steingroewer J , et al . J . Magn.Magn. Mater. , 2005 , 293 : 224 —239
[26] Hargreaves K A , Heimfeld A , Berenson R J . Bioconjugate Chem. , 1994 , 5 : 287 —300
[27] Bessette P H , Daugherty P S. Biotechnol . Prog. , 2004 , 20 :963 —967
[28] McCloskey K E , Chalmers J J , Zborowski M. Cytometry , 2000 ,40 : 307 —315
[29] McCloskey K E , Zborowski M, Chalmers J J . Cytometry , 2001 ,44 : 137 —147
[30] Lee S J , Lee S Y. Appl . Microbiol . Biotechnol . , 2004 , 64 :289 —299
[31] Roddy E S , Xu H , Ewing A G. Electrophoresis , 2004 , 25 :229 —242
[32] Schwartz A , Fernandez R E , Vogt R G. Cytometry , 1996 , 26 :22 —31
[33] Williams P S , Decker K, Nakamura M, et al . Anal . Chem. ,2003 , 75 : 6687 —6695
[34] Reyes D R , Iossifidis D , Auroux P A , et al . Anal . Chem. ,2002 , 74 : 2623 —2636
[35] Auroux P A , Iossifidis D , Reyes D R , et al . Anal . Chem. ,2002 , 74 : 2637 —2652
[36] Verpoorte E. Electrophoresis , 2002 , 23 : 677 —712
[37] Pamme N , Manz A. Anal . Chem. , 2004 , 76 : 7250 —7256
[38] Jiang G, Harrison D J . Analyst , 2000 , 125 : 2176 —2179
[39] Hayes M A , Polson N A , Phayre A N , et al . Anal . Chem. ,2001 , 73 : 5896 —5902
[40] Fan Z H , Mangru S , Granzow R , et al . Anal . Chem. , 1999 ,71 : 4851 —4859
[41] Choi J W, Oh K W, Thomas J H , et al . Lab Chip , 2002 , 2 :27 —30
[42] Furdui V I , Kariuki J K, Harrison D J . J . Micromech.Microeng. , 2003 , 13 : S164 —S170
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