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Progress in Chemistry 2005, Vol. 17 Issue (06): 1048-1053 Previous Articles   Next Articles

• Review •

The Development of the Carbenium Transition State Analogs

Liao Guihong;He Hongwu**   

  1. Key Laboratory of Pesticide &Chemical Biology , Ministry of Education,College of Chemistry,Central China Normal University,Wuhan 430079,China
  • Received: Revised: Online: Published:
  • Contact: He Hongwu
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An important feature in the enzyme catalyzed reaction is that an enzyme recognizes and binds more tightly to the transition state than to the ground state of the substrate product interconversion. The transition state analog must be a potent inhibitor of the enzyme.The recent development of the carbenium transition state analogs as the enzymatic inhibitors which are designed by the transition state theory of enzyme catalyzed reactions is reviewed. Four types of enzymatic inhibitors including the transition state analogs of isoprenoid pyrophosphate,sialyltransferase,KDO8P and UGT are introduced.
Key words: enzyme, carbenium, transition state analogs, inhibitors

CLC Number: 

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