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Progress in Chemistry 2005, Vol. 17 Issue (05): 916-923 Previous Articles   Next Articles

• Review •

Advances in L-Nucleosides as Anti-HIV and Anti-HBV Agents

Dong Chunhong1;Chang Junbiao1,2*   

  1. 1.Department of Chemistry, University of Science and Technology of China,Hefei 230027,China;

    2.The Research Center of Henan Academy of Sciences, Zhengzhou 450002,China

  • Received: Revised: Online: Published:
  • Contact: Chang Junbiao
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Drug discovery for anti-HIV, anti-HBV chemotherapy has provided the effective clinical treatment. Among these antiviral agents used in therapy, nucleoside analogues are particularly useful. In this paper, the antiviral mechanism of the nucleoside analogues, the discovery of L-nucleoside and the classificalion of some new anti-HIV, anti-HBV L-nucleoside analogues are introduced. In addition, the datum of two enantiomers of some anti-HIV, anti-HBV nucleoside analogues indicate that the bioactivities and securities of L-nucleoside analogues is superior to the counterpart enantiorners. As a result, the medicinal chemists have focused their attention on designing and preparing new L-nucleoside analogues to search for more powerful and securer new antiviral agents.
Key words: L-nucleosides, anti-HIV, anti-HBV

CLC Number: 

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