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Progress in Chemistry 2005, Vol. 17 Issue (05): 905-910 Previous Articles   Next Articles

• Review •

Progress in Study of Protein Denaturation and Thermodynamic Parameters of Denaturation

Lu Yan**;Li Xiangrong   

  1. College of Chemistry and Environmental Science, Henan Normal University,Xinxiang 453007,China
  • Received: Revised: Online: Published:
  • Contact: Lu Yan
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The study of biological macromolecules has been one of the popular and difficult research area in liie science in recent years. The study of protein denaturation is conductive to reveal the mechanism of living phenomenon. Using the methods of spectroscopy and thermodynamics, one can study the problems of protein denaturation from the microscopic and macroscopic aspects respectively. The thermodynamic parameters which manifest the protein denaturation can be obtained in the study. All the studies are significant to understand more deeply and precisely the folding and unfolding, the stability and denaturation of proteins and the metabolism in living systems. In recent years, much hard work has been done by scholars from all over the world. These work has mainly involved the denaturation mechanism of proteins in water, in the solution with denaturant and in the solution with other matters. The thermodynamic parameters, which be used to manifest the protein denaluration, are heat capacity, Gibbs free energy, enthalpy and entropy. The recent progress in study of protein denaturation is reviewed.
Key words: proteins, denaturation, thermodynamic parameters

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