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Progress in Chemistry 2005, Vol. 17 Issue (04): 740-748 Previous Articles   Next Articles

• Review •

Hydroxylated Metabolites of Polychlorinated Biphenyls and Their Endocrine Disrupting Mechanism

Yang Fangxing1,2;Xu Ying1**   

  1. 1.State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences,Wuhan 430072,China;

    2.Graduate School of the Chinese Academy of Sciences,Beijing 100039,China

  • Received: Revised: Online: Published:
  • Contact: Xu Ying
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Hydroxylated polychlorinated biphenyls ( OH-PCBs ), a group of main active metabolites of polychlorinated biphenyl (PCBs) which are typical persistent organic pollutants (POPs), have been identified in wild animals and human. The endocrine disruption of OH-PCBs has been drawn great attention due to the similarity of their chemical structures to the natural estrogens and thyroid hormones. The metabolic pathways of PCBs, the levels of OH-PCBs in organism,the endocrine disruption and other adverse effects of OH-PCBs are reviewed. The further investigation of OH-PCBs will not only reveal the toxicological mechanism of PCBs,but also can lay scientific basis for setting up the risk assessment of POPs contamination and early-warning system in China.
Key words: polychlorinated biphenyls, hydroxylated polychlorinated biphenyls, OH-PCBs, endocrine disruption

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