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Progress in Chemistry 2005, Vol. 17 Issue (04): 692-699 Previous Articles   Next Articles

• Review •

DNA-Templated Organic Synthesis

Xiao Yumei;Fu Bin;Li Nan;Qin Zhaohai*   

  1. College of Science , China Agriculture University,Beijing 100094,China
  • Received: Revised: Online: Published:
  • Contact: Qin Zhaohai
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DNA template directs organic synthesis by sequence-specificity recruiting reactants linked to complementary DNA. The numerous types of DNA-templated organic synthesis, including reductive animation, nucleophilic substitution, Henry, Wittig olefination, photochemical ligation and multistep small-molecule synthesis, etc, are reviewed. DNA-templated combinational library is also discussed. The effects of DNA architectures on reactions and stereoseletivity in the reactions are summarized .
Key words: DNA template, organic synthesis, sequence-specificity, combinational library, stereoseletivity

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Abstract

DNA-Templated Organic Synthesis