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Progress in Chemistry 2005, Vol. 17 Issue (01): 78-84 Previous Articles   Next Articles

• Review •

Progress in Metal Complex Conjugated to an Oligodeoxyribonucleotide as Selective Cleavage Reagent

Yuan Caixia    Yang Pin * *   

  1. ( The Key Laboratory of Chemical Biology andMolecular Engineering, Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China)
  • Received: Revised: Online: Published:
  • Contact: Yang Pin E-mail:yangpin@ sxu. edu. cn
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The artificial enzymes, which are prepared by cleavage reagents of nucleic acid conjugated to a synthet ic oligodeoxyribonucleotide, can selectively cleave DNA or RNA. It provides a new method of the molecular design of artifi?? cial nuclease. In this review the conjugation mode of metal complex with an oligodeoxyribonucleotide and the interaction mechanism of the artificial enzymes with the targets are described, and the research direction in future is pointed out .

Key words: metal complex, oligodeoxynucleotide, conjugation, artificial nuclease, selective cleavage

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