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Progress in Chemistry 2004, Vol. 16 Issue (06): 975- Previous Articles   Next Articles

• Review •

Application of Microfluidic Chip Systems for the Research of Single Cell

Gao Jian;Yin Xuefeng**;Fang Zhaolun   

  1. (Institute of Microanalytical Systems, Department of Chemistry,Zhejiang University, Hangzhou 310027, China)
  • Received: Revised: Online: Published:
  • Contact: Yin Xuefeng
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The development of microfluidic chip system provides a new platform for the research of single cell. Be-cause the sophistication and variety of microdevices and systems being built, the ability to study life at the cellular level and below is extended. On the microfluidic chip, an individual cell can be controlled and handled easily by use of pneu-matic pressure, hydraulic pressure, voltage, dielectrophoresis force (DEP), optical trapper, traveling-wave dielectro-phoresis (twDEP) and magnetic field, etc. The couplings of above techniques with microfluidic chip systems can operate the single cells to transit or dock anywhere in the micro channels. So the operations of single cell's counter, sorting and analysis were achieved conveniently. In this paper, the applications of microfliudie systems on blood rheology, counter or sorting, and intracellular contents analysis are reviewed. Several microfliudie chip.systems used for study single cell are introduced. The operation methods on single cell are discussed.
Key words: microfluidic chip, single cell, countering, sorting, intracellular contents analysis

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