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Progress in Chemistry 2004, Vol. 16 Issue (02): 313- Previous Articles   

• Review •

From Bioorganic Chemistry to Chemical Biology

Zhang Lihe   

  1. (School of Pharmaceutical Sciences, Peking University, Beijing 100083, China)
  • Received: Revised: Online: Published:
  • Contact: Zhang Lihe
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Small molecules have long been associated with biological discoveries. Bioorganic chemistry is a new discipline emerging from the interaction of biology and organic chemistry especially in the field to study the binding of a small molecule to the protein that results in a perturbation of function, either inhibition or activation. Chemical biology and diversity-oriented organic synthesis make possible the systematic exploration of biology and artificial transcription factors be used as a probe for the discovery of new insights into life processes.
Key words: bioorganic chemistry, chemical biology, artificial transcription factors

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[ 1 ] Watson J D , Crick F H C. Cold Spring Harbor Symp. Quant . Biol . , 1973 , 18 : 123 —131
[ 2 ] Bioorganic Chemistry , (ed. van Tamelen E E) , Vols. I-IV. New York : Academic Press , 1977
[ 3 ] Breslow R (ed. ) . International Symposiumon Bioorganic Chemistry ,in Ann. New York Acad. Sci . , 1986 , 471
[ 4 ] Lehn J M. Angew. Chem. Int . Ed. Engl . , 1988 , 27 : 89 —112
[ 5 ] Cram D J . Science , 1988 , 240 : 760 —767
[ 6 ] Pederson C J . Science , 1988 , 241 : 536 —541
[ 7 ] Deakyne C A , Allen L C. J . Am. Chem. Soc. , 1977 , 101 :3951 —3959
[ 8 ] Westheimer F H. Acc. Chem. Res. , 1968 , 1 :70 —78
[ 9 ] Usher D A , Erenich E S , Eckstein F. Proc. Natl . Acad. Sci .USA , 1972 , 69 : 115 —118
[10] Navia M A , Fitzgerald M D , Mckeever B M. Nature , 1989 , 337 :615 —620
[11] Brik A , Wong C H. Org. &Biomol . Chem. , 2003 , 1 : 5 —14
[12] Schreiber S L. Chem. & Eng. News , 2003 , March 3 : 51 —61
[13] Mapp A K. Org. &Biomol . Chem. , 2003 , 1 (13) : 2217 —2220
[14] Guo Z H , Zhou D M, Schultz P G. Science , 2000 , 288 : 2042 —2045
[15] Eisenmesser E K, Bosco D A , Kern M A. Science , 2002 , 295 :1520 —1524
[16] Estebbins C E , Galan J E. Nature , 2001 , 414 : 77 —82
[17] Reerli R R , Dreier B , Barnas III C F. Proc. Natl . Acad. Sci .USA , 2000 , 97 :1495 —1500
[18] Rivera V M, Wang X, Wardwell S. Science , 2000 , 287 : 827 —830
[19] Martin S E , Peterson B R. Bioconjugate Chem. , 2003 , 14 : 67 —74
[20] Weatherman R V. Organic Biomolecular Chemistry , 2003 , 1(19) : 3257 —3260
[21] Gaylord B S , Heeger A J , Bazan G C. Proc. Natl . Acad. Sci .USA , 2002 , 99 : 10954 —10957
[22] Biggins J B , Prudent J R , Marshall D J . Proc. Natl . Acad. Sci .USA , 2000 , 97 : 13537 —13542
[23] Keller U. Nature , 2003 , 424 : 831 —838
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