中文
Earlier issues
Announcement
More
Progress in Chemistry 2004, Vol. 16 Issue (01): 105- Previous Articles   Next Articles

• Review •

High-Throughout Protein Crystallization and Its Application to Drug Design*

Zhao Weiguang;Li Zhengming**;Wang Baolei;Wang Jianguo   

  1. (Research Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China)
  • Received: Revised: Online: Published:
  • Contact: Li Zhengming
PDF ( 2839 ) Cited
Export

EndNote

Ris

BibTeX

Information of 3D structure of proteins can play a key role in developing small-molecule drugs that inter-act with targets. High-throughout protein X-ray crystallography offers an unprecedented opportunity to facilitate structure determination and drug discovery. The recent advances in high-throughout protein crystallization and the application to drug design are discussed in this review.
Key words: high-throughout, protein crystallization, drug design

CLC Number: 

[ 1 ] Terret N K, Gardner M, Jordon D , Kobylecki RJ , Steele T. Tetrahedron , 1995 , 51 : 8135 —8173
[ 2 ] Thompson L A , Ellman J A. Chem. Rev. , 1996 , 96 : 555 —600
[ 3 ] Labana R. Drug Discovery Today , 1999 , 4 (10) : 447 —448
[ 4 ] Venter J C , Adms M D , Myers E W, et al . Science , 2001 , 291 :1304 —1351
[ 5 ] Dogen van M, Weigelt J , Uppenberg J , Schultz J , Wikstrêm M.Drug Discovery Today , 2002 , 7 (8) : 471 —477
[ 6 ] Amzel L M. Curr. Opin. Biotech. , 1998 , 9 : 366 —369
[ 7 ] Abbott A. Nature , 408 , 2000 : 130 —132
[ 8 ] Blundell T. Nature , 1996 , 384 : S23 —S26
[ 9 ] Drews J . Science , 2000 , 287 : 1960 —1964
[10] Goodwill K E , Tennant M G, Stevens R C. Drug Discovery Today , 2001 , 6 (15) suppl . : S113 —S118
[11] Heinemann Udo , Hahn M. Current Opinion in Biotechnology ,2001 , 12 (4) : 348 —354
[12] 王弘(Wang H) , 于淑娟(Yu S J ) , 高大维(Gao D W) . 生命的化学(Chem. Life) , 2001 , 21 (5) : 429 —431
[13] Jhoti H. Trends in Biotech. , 2001 , 19 (10) , Supp : S67 —S71
[14] Heinemann U , Illing G, Oschkinat H. Curr. Opin. Biotech. ,2001 , 12 : 348 —354
[15] Lanio T, Jeltsch A , Pingoud A. Bio. Techniques , 2000 , 29 :338 —342
[16] McPherson A. J . Cryst . Growth , 1992 , 122 : 161 —167
[17] Chayen N E. Acta Cryst . , 1998 , D54 : 8 —15
[18] http://iccbm8.cmc.uab.edu/Abstracts/Luft-1.html
[19] Stevens R C. Current Oppinion in Structural Biology , 2000 , 10(5) : 558 —563
[20] Baird J K. J . Cryst . Growth , 1999 , 204 : 553 —562
[21] Kim H , Stewart L. US 6 039 804 , 2000
[22] Krogh A , Larsson B , von Heijne G R. J . Med. Biol . , 2001 ,305 : 567 —580
[23] Luecke H , Schobert B , Richter H T, et al . J . Mol . Biol . ,1999 , 291 : 899 —911
[24] Kolbe M, Besir H , Essen L O , et al . Science , 2000 , 288 :1390 —1396
[25] Luecke H , Schobert B , Lanyi J K, et al . Science , 2001 , 293 :1499 —1503
[26] Lancaster C R , Bibikova M V , Sabatino P , et al . J . Biol .Chem. , 2000 , 275 : 39364 —39368
[27] McLuskey K, Prince S M, Cogdell R J , et al . Biochemistry ,2001 , 40 : 8783 —8789
[28] de Groot H J M. Current Opinion in Structural Biology , 2000 , 10(5) : 593 —600
[29] Malkin A J . Kuznetsov Y G, McPherson A. Proteins , 1996 , 24 :247 —252
[30] http://iccbm8.cmc.uab.edu/Abstracts/Saenger-1.html
[31] Hendrickson W A. Trends in Biochem. Sci . , 2000 , 25 : 637 —643
[32] Service R F. Science , 1999 , 285 : 1342 —1346
[33] Muchmore S W, Olson J , Jones R , et al . Structure , 2000 , 8 :R243-R-46
[34] Lamzin V S , Wilson K S. Acta Cryst . , 1993 , D49 : 129 —147
[35] Oldfield T J . Acta Cryst . , 2001 , D57 : 696 —705
[36] Stewart L , Clark R , Behnke C. Drug Discovery Today , 2002 , 7(3) : 187 —196
[37] Amzel L M. Current Opinion in Biotechnology , 1998 , 9 ( 4) :366 —369
[38] Carlson H A , McCammon J A. Molecular Pharmacology , 2000 ,57 : 213 —218
[39] Gane P J , Dean P M. Curr. Opin. Struct . Biol . , 2000 , 10 :401 —404
[40] Verkhivker G M, Bouzida D , Gehlhaar D. J . Comput . Aided Mol . Des. , 2000 , 14 : 731 —751
[41] Klebe G. J . Mol . Med. , 2000 , 78 : 269 —281
[42] Nienaber V L , Richardson P L , Klighofer V. Nat . Biotechnol . ,2000 , 18 (10) : 1105 —1108
[43] Bernstein B E , Hol W G. Biochemistry , 37 : 4429 —4436
[44] Carr R , Jhoti H. Drug Discovery Today , 2002 , 7 (9) : 522 —527
[45] Oprea T I. J . Chem. Inf . Comput . Sci . , 201 , 41 : 1308 —1315
[46] Hann M. Leach A R. Harper G. J . Chem. Inf . Comput . Sci . ,2001 , 41 : 856 —864
[47] Shuker S B , Hajduk P J , Meadows R P , et al . Science , 1996 ,274 : 1531 —1534
[48] Boehm H J , Boehringer M, Bur D , et al . J . Med. Chem. ,2000 , 43 : 2664 —2674
[49] Bemis G W, Murcko M A. J . Med. Chem. , 1996 , 39 : 2887 —2893
[50] Bemis G W, Murcko M A. J . Med. Chem. , 1999 , 42 : 5095 —5099
[51] Bailey D , Brown D. Drug Discovery Today , 2001 , 6 (2) : 57 —59
[52] Dongen M van , Weigelt J , Uppenberg J , et al . Drug Discovery Today , 2002 , 7 (8) : 471 —477
[53] Fejzo J , Lepre C A , Peng J W, et al . Chemistry & Biology ,1999 , 6 (10) : 755 —769
[1] Tong Wang, Wenjiao Zhao, Liangchun Li, Renlin Zheng, Dequn Sun. Synthesis of Dehydroamino Acids and Their Applications in the Drug Research and Development [J]. Progress in Chemistry, 2020, 32(1): 55-71.
[2] Zhan Peng, Wang Xueshun, Liu Xinyong. Contemporary Molecular Targeted Drug in the Context of “Precision Medicine”: An Attempting Discussion of “Precision Drug Design” [J]. Progress in Chemistry, 2016, 28(9): 1363-1386.
[3] Yuan Shuo, Sun Dequn. The Conformational Restriction of β-Peptidomimetics in Drug Design [J]. Progress in Chemistry, 2016, 28(7): 1084-1098.
[4] Hou hui, Sun Dequn. Conformational Restriction of Peptidomimetics in Drug Design [J]. Progress in Chemistry, 2015, 27(9): 1260-1274.
[5] Ren Yanrong, Tian Feifei, Zhou Peng. Computational Peptidology [J]. Progress in Chemistry, 2012, (9): 1674-1682.
[6] . "Click Chemistry" and Its Growing Applications in Biomedical Field [J]. Progress in Chemistry, 2010, 22(0203): 417-426.
[7] Li Junjun Chen Qiang Li Gang Zhao Jianlong Zhu Ziqiang. Research and Application of Microfluidics in Protein Crystallization [J]. Progress in Chemistry, 2009, 21(05): 1034-1039.
[8] 刘幸海 XingHai Liu. Progress in KARI and its Inhibitors [J]. Progress in Chemistry, 2008, 20(11): 1788-1797.
[9] Han Chunyan|Li Yan|Liu Gang**

. Drug-likeness: Predication and Practice [J]. Progress in Chemistry, 2008, 20(09): 1335-1344.
[10] Zhang Na1,Jiang Yongjun2**|Yu Qingsen1,Zou Jianwei2. Studies of Glycogen Synthase Kinase-3 Inhibitors [J]. Progress in Chemistry, 2007, 19(04): 614-623.
[11] Guizhao Liang1,Hu Mei1,Yuan Zhou1,Zhiliang Li 1,2*. Modeling Techniques of Multidimensional Quantitative Structure-Activity Relationship in Computer-Aided Drug Design [J]. Progress in Chemistry, 2006, 18(01): 120-130.
[12] Hou Tingjun,Xu Xiaojie*. Applications of Genetic Algorithms to Computer-Aided Drug Design [J]. Progress in Chemistry, 2004, 16(01): 35-.
[13] Wang Baolei,Li Zhengming*,Cang Hongjun. Influence of Genomics on Structure-based Drug Design [J]. Progress in Chemistry, 2003, 15(06): 505-.
[14] Zhou Jiaju,Lei Jing,Xie Guirong,Li Renli. Peptidomimetics in Drug Design [J]. Progress in Chemistry, 2000, 12(03): 332-.
[15] Xu Jun. Chemical Diversity Exploration and Combinatorial Chemistry in Drug Discovery [J]. Progress in Chemistry, 1999, 11(03): 286-.