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Progress in Chemistry 2003, Vol. 15 Issue (05): 393- Previous Articles   Next Articles

• Review •

Peptide Segments Ligation and Synthesis of Peptide Thioester and Peptide Aldehyde

Ma Yuan**;Zhao Yufen   

  1. (Bioorganic Phosphorus Chemistry Key Laboratory of Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, China)
  • Received: Revised: Online: Published:
  • Contact: Ma Yuan
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This review focuses on peptide segment ligation for synthesis of peptides and proteins. Ligation is a new methodology in peptide and protein synthesis chemistry. Peptide and protein can be obtained with high yield in aqueous buffer by coupling unprotected peptide segments without activation by enzymatic or chemical agents. The synthetic methods of peptide thioester and peptide aldehyde are also discussed.
Key words: peptide, protein, segment ligation, peptide thioester, peptide aldehyde

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