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Progress in Chemistry 2003, Vol. 15 Issue (03): 186- Previous Articles   Next Articles

• Review •

Progress in Ugi Reaction

Ma Ning;Li Zhengming*;Zhao Weiguang   

  1. (Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China; Elemento-Organic Chemistry Institute, College of Chemistry, Nankai University, Tianjin 300072, China)
  • Received: Revised: Online: Published:
  • Contact: Li Zhengming
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Ugi reaction is an important reaction used in combinatorial chemistry. The development and applications of this reaction in recent years were reviewed on three aspects: (1) Variation of four components, including aldehyde (ketone), amine, acid and isocyanide, especially variation of the isocyanide and use of bifunctional compounds; (2) Ugi reaction for more than four components; (3) Applications of Ugi reaction in the synthetic process of some natural and drug-like compounds.
Key words: Ugi reaction, combinatorial chemistry, isocyanide

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Abstract

Progress in Ugi Reaction