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Progress in Chemistry 2002, Vol. 14 Issue (05): 355- Previous Articles   Next Articles

• Review •

Progress in Tyrosine Kinase Inhibitor

Peng Tao;Zhou Jiaju   

  1. Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China
  • Received: Revised: Online: Published:
  • Contact: Peng Tao
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Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions. Tyrosine kinases are attractive as targets in the research of therapeutic agents, not only against cancer, but also against many other diseases. The progress in tyrosine kinase inhibitor has been reviewed, including the chemical structures and the pharmacophore models.
Key words: tyrosine kinases, inhibitors, ATP, pharmacophore models

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[ 1 ] Burker T R. Drugs Future, 1992, 17: 119—131
[ 2 ] Fry D W. Exp. Opin. Invest. Drugs, 1994, 3: 577—595
[ 3 ] Traxler P, Lydon N. Drugs Future, 1995, 20: 1261—1274
[ 4 ] 韩锐. 肿瘤化学预防及药物治疗. 北京: 北京医科大学出版社, 1991. 182
[ 5 ] Graziani Y, Chayoth R, Karny N , et al. Biochem. Biophys. Acta, 1981, 714: 415—433
[ 6 ] 庞素华(Pang S H) , 郭宗儒(Guo Z R ). 药学学报(Acta Pharma. Sinica) , 1996, 31 (1) : 75—80
[ 7 ] Fry D W , Kraker A J , McMichael A , et al. Science,1994, 265: 1093—1095
[ 8 ] Showalter H, Sercel A , Leja B, et al. J. Med. Chem. ,1997, 40: 413—426
[ 9 ] Bredges A , Zhou H, Cody D, et al. J. Med. Chem. ,1996, 39: 267—276
[ 10 ] Rewcastle G, Palmer B, Bredges A , et al. J. Med.Chem. , 1996, 39: 918—928
[ 11 ] Rewcastle G, Palmer B, Thompson A , et al. J. Med.Chem. , 1996, 39: 1823—1835
[ 12 ] Palmer B, Trumpp-Kallmeyer S, Fry D, et al. J. Med.Chem. , 1997, 40: 1519—1529
[ 13 ] Rewcastle G, Bridges A , Fry D, et al. J. M ed. Chem. ,1997, 40: 1820—1826
[ 14 ] Thompson A , Murray D, Elliott W , et al. J. Med.Chem. , 1997, 40: 3915—3925
[ 15 ] Rewcastle G, Murray D, Elliott W , et al. J. Med.Chem. , 1998, 41: 742—751
[ 16 ] Smaill J , Palmer B, Rewcastle G, et al. J. Med. Chem. ,1999, 42: 1803—1815
[ 17 ] Showalter H, Gridges A , Zhou H, et al. J. Med. Chem. ,1999, 42: 5464—5474
[ 18 ] Smaill J , Rewcastle G, Loo J , et al. J. Med. Chem. ,2000, 43: 1380—1397
[ 19 ] Smaill J , Showalter H, Zhou H, et al. J. Med. Chem. ,2001, 44: 429—440
[ 20 ] Bo schelli D, W u Z, Kltchko S, et al. J. Med. Chem. ,1998, 41: 4365—4377
[ 21 ] Traxler P, Green J , Mett H, et al. J. Med. Chem. ,1999, 42: 1018—1026
[ 22 ] Traxler P. Exp. Opin. Ther. Patents. , 1997, 7: 571—588
[ 23 ] Traxler P, Furet P, Mett H, et al. J. Med. Chem. ,1996, 38: 2285—2292
[ 24 ] Traxler P, Bold G, Frei J , et al. J. Med. Chem. , 1997,40: 3601—3616
[ 25 ] Sun L , Tran N , Tang F, et al. J. Med. Chem. , 1998,41: 2588—2603
[ 26 ] Hennequin L , Thomas A , Johnstone C, et al. J. Med.Chem. , 1999, 42: 5369—5389
[ 27 ] 庞素华(Pang S H) , 郭宗儒(Guo Z R) , 梁晓天(Liang X T). 药学学报(Acta Pharma. Sinica) , 1997, 32 (7) : 515—523
[ 28 ] Furet P, Caravatti G, Lydon N , et al. J. Comput. Aided Mol. Des. , 1995, 9: 465—471
[ 29 ] Traxler P, Furet P. Phamacol. Ther. , 1999, 82: 195—206
[ 30 ] Palmer B D, Trumpp-Kallmeyer S, Fry D W , et al. J.Med. Chem. , 1997, 40: 1519—1529
[ 31 ] Trumpp-Kallmeyer S, Rubin J R, Humblet C, et al. J.Med. Chem. , 1998, 41: 1752—1763
[ 32 ] 郭宗儒(Guo Z R) , 后藤了(Goto S) , 杨光中(Yang G Z)等. 药学学报(Acta Pharma. Sinica) , 1992, 27 (2) : 90—95
[ 33 ] 廖宁(Liao N ) , 侯廷军(Hou T J ) , 陈丽蓉(Chen L R) 等.计算机与应用化学(Computer and Applied Chemistry) ,2000, 17 (1) : 37—38
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Abstract

Progress in Tyrosine Kinase Inhibitor