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Progress in Chemistry 2001, Vol. 13 Issue (06): 428- Previous Articles   Next Articles

• Review •

Recent Progress in Studies of Mechanism for DNA Photoreactivation

Song Qinhua;Guo Qingxiang   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
  • Received: Revised: Online: Published:
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Cyclobutane pyrimidine dimers (Pyr< > Pyr) are the major DNA photoproducts induced by the UV radiation. Photo reactivating enzyme (DNA photolyase) repairsDNA by utilizing the energy of visible light to break the cyclobutane ring of the dimer. In this paper, binding and splitting mechanism of pyrimidine dimer by DNA photolyase were reviewed. The structure of DNA photolyases and the UV induced DNA photoproducts were introduced. In particu lar, recent research progress in photo repair mechanism of the photolyase was discussed.
Key words: photoreactivation, DNA photolyase, cyclobutane pyrimidine dimer, molecula recognition, photorepair

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