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Progress in Chemistry 2001, Vol. 13 Issue (04): 283- Previous Articles   Next Articles

• Review •

Progress in the Design of Matrix Metalloproteinase Inhibitors

Cheng Feng;Liu Hong;Luo Xiaomin;Jiang Hualiang**;Shen Jingkang;Chen Kaixian;Ji Ruyun   

  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China
  • Received: Revised: Online: Published:
  • Contact: Jiang Hualiang
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Matrix metalloproteinase (MMP) is a family of zinc proteinases. The excess of these proteinases leads to the accelerated extracellular matrix degradation associated with diseases such as arthritis, cancer and multiple sclerosis. The research of MMP inhibitors is an active field of drug design. In recent years, three methods of molecular design have been developed, including substrate based design, structure based design and combinatorial chemistry technology. The principle of these methods and their applications in MMP inhibitor design are summarized in this review.
Key words: matrix metalloproteinase, inhibitor, substrate based design, structure based design, combinatorial chemistry, SAR by NMR

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