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Progress in Chemistry 2001, Vol. 13 Issue (03): 216- Previous Articles   Next Articles

• Review •

Molecular Design of Metalloporphyrin as Oxidative Cleavage Agent for DNA in Site-Sequence Specific Way

He Hongshan   

  1. School of Chemical Engineering, National Huaqiao University, Quanzhou 362011, China
  • Received: Revised: Online: Published:
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Metalloporphyrin as a sitesequence specific cleavage agent of nucleic acids plays an important role in the design of structural probes and therapeutic agents. Metalloporphyrins linked to the special groups (oligonucleo tides, peptides, acridine etc. ) can cleave the DNA in a sequence specific ways in the presence of oxidants, which will have apotential application in molecular biology. This article reviews the design, synthesis and oxidation properties of various metalloporphyrin related cleavage agents in recent years.
Key words: metalloporphyrins, DNA, recognition in sitesequence specific way, oxidative cleavage

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