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Progress in Chemistry 2000, Vol. 12 Issue (04): 401- Previous Articles   Next Articles

• Review •

The Biosynthesis of Polyketides

Shen Yuemao;Gan Fanyuan;Du Liangcheng;Hao Xiaojiang*   

  1. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
  • Received: Revised: Online: Published:
  • Contact: Hao Xiaojiang
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During recent ten years, the research on biosynthesis of natural products,particularly of poly ketides has made staggering progress with the application of the methods and techniques transplanted from molecular biology in to bioorganic chemistry.The biosynthetic path ways of natural poly ketides were briefly reviewed in this article.

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[1 ] Collie N J , J. Chem. Soc. , 1893, 63, 329.
[2 ] Collie N J , Proc. Chem. Soc. (London) , 1907, 23, 230.
[3 ] Robinson R, J. Roy. Soc. Arts, 1948, 96, 795.
[4 ] Birch A J , Donovan F W , Austral. J. Chem. , 1953, 6, 360.
[5 ] O’Hagan D, The Polyketide Metabolites, Horwood, Chichester, 1991.
[6 ] Rawlings B J , Nat. Prod. Rep. , 1999, 16, 425.
[7 ] Rawlings B J , Nat. Prod. Rep. , 1997, 14, 523.
[8 ] O’Hagan D, Nat. Prod. Rep. , 1995, 12, 1; 1993, 10, 593; 1992, 9, 447.
[9 ] Simpson T J , Nat. Prod. Rep. , 1991, 8, 573; 1987, 4, 339; 1985, 2, 321; 1984, 1, 28.
[10 ] Malpartida F, Hopwood D A , Nature, 1984, 309, 462.
[11 ] Shen Y, Doctoral Dissertation, Kunming Institute of Botany, CA S, 1998.
[12 ] Donadio S, Staver M J , Mcalpine J B, Swanson S J , Katz L , Science, 1991, 252, 675.
[13 ] Hahlbrock K, in Biochemistry of Plants (ed. Conn E E) , Academic Press, New York, 1981, 425—456.
[14 ] Hutchinson C R, Chem. Rev. , 1997, 97, 2525.
[15 ] Thomas R, Williams D J , J. Chem. Soc. , Chem. Commun. , 1983, 667.
[16 ] Thomas R, Williams D J , J. Chem. Soc. , Chem. Commun. , 1985, 802.
[17 ] Yu T W , Shen Y, Doi-Katayama Y, Tang L , Park C, Moore B S, Hutchinson C R, Floss H G,Proc. Natl. Acad. Sci. USA , 1999, 96, 9051.
[18 ] Walters D S, Craig R, Mumma R O , Phytochemistry , 1990, 29, 1815.
[19 ] Harris T M , Harris C M , Pure &Appl. Chem. , 1986, 58, 283.
[20 ] Donadio S, Staver M J , Mcalpine J B, Swanson S J , Katz L , Gene, 1991, 115, 97.
[21 ] McDaniel R, Ebert-Khosla S, Hopwood D A , Khosla C, S cience, 1993, 262, 1546.
[22 ] Thomas R, Williams D J , J. Chem. S oc. , Chem. Comm un. , 1985, 802.
[23 ] Mahler H R, Cordes E H, Biological Chemistry (2nd ed. ) , Harper and Row , New York, 1971.
[24 ] Staunton J , Primary Metabolism : a Mechanistic Approach, Clarendon Press, Oxford, 1978.
[25 ] Lynen F, Eur. J. Biochem. , 1980, 112, 431.
[26 ] Katz L , Chem. Rev. , 1997, 97, 2557.
[27 ] Hopwood D A , Chem. Rev. , 1997, 97, 2465.
[28 ] McDaniel R, Ebert-Khosla S, Hopwood D A , Khosla C, J. Am. Chem. Soc. , 1993, 115, 11671.
[29 ] Fu H, Ebert-Khosla S, Hopwood D A , Khosla C, J. Am. Chem. Soc. , 1994, 116, 4166.
[30 ] McDaniel R, Ebert-Khosla S, Hopwood D A , Khosla C, Science, 1993, 262, 1546.
[31 ] Brockmann H, Angew. Chem. , 1964, 76, 863.
[32 ] Gorst-Allman C P, Rudd B A , Chang C J , Floss H G, J. Org. Chem. , 1981, 46, 455.
[33 ] Yu T W , Shen Y, McDaniel R, Floss H G, Khosla C, Hopwood D A , Moore B S, J. Am. Chem.Soc. , 1998, 120, 7749.
[34 ] Shen Y, Yoon P, Yu T W , Floss H G, Hopwood D A , Moore B S, Proc. Natl. Acad. Sci. USA ,1999, 96, 3622.
[35 ] Lanz T , Tropf S, Marner F J , Schroeder J , Schroeder G, J. Biol. Chem. , 1991, 266, 9971.
[36 ] Reimold U , Kroeger M , Kreuzaler F, Hahlbrock K, EM BO J. , 1983, 2, 1801.
[37 ] Schroeder J , Schroeder G, Z. Naturforsch. , 1989, 45c, 1.
[38 ] Jolad S D, Hoffmann J , Schram K H, Cole J R, J. Org. Chem. , 1982, 47, 3151.
[39 ] Zeng L , Ye Q , Oberlies N H, Shi G, Gu Z, He K, Nat. Prod. Rep. , 1996, 13, 275.
[40 ] Kurosaki F, Itoh M , Kizawa Y, NishiA , Arch. Biochem. Biophys. , 1993, 300, 157.
[41 ] Kurosaki F, Itoh M , Nishi A , Phytochemistry , 1994, 35, 297.
[42 ] Kurosaki F, Phytochemistry , 1994, 37, 727.
[43 ] Reinecke T , Kindle H, Phytochemistry , 1994, 35, 63.

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Abstract

The Biosynthesis of Polyketides