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Progress in Chemistry 1999, Vol. 11 Issue (04): 403- Previous Articles   Next Articles

• Review •

Biology Functions of Nucleoprotein and Synthesis, Applications of Nucleopeptide

Tian Xiaobing;Min Jimei;Zhang Lihe   

  1. National Research Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 10083, China
  • Received: Revised: Online: Published:
  • Contact: Zhang Lihe
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Nucleoprotein or nucleopeptide is a class of natural macromolecules in which the protein or peptide cores are combined with DNA or RNA at 3′or 5′end by phosphodiester linkages in their side chain. They exhibit broad biological effects including the proliferation of DNA and RNA and the transcription, interaction, deletion, reformation of DNA etc. Nucleopeptides can be synthesized as the fragments of nucleoprotein at binding position and used as a tool for the investigation of the mechanism of biological effects of nucleoproteins. It will open a way to the search for anticancer and antiviral drugs.

Key words: nucleoprotein, nucleopeptide, biological effects, proliferation, synthesis, anticancer drugs, antiviral drugs

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