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Progress in Chemistry 1997, Vol. 9 Issue (03): 273- Previous Articles   Next Articles

• Review •

Chemical Nucleases and Their Acting Mechanisms

Yang Pin;Gao Fei;Ma Guibin   

  1. (Institute of Molecular Science, Shanxi University, Taiyuan 030006, China)
  • Received: Revised: Online: Published:
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Chemical nucleases are newly designed and synthesized compounds which used as tools of DNA or RNA cleavage in a sequence specific way. They consist of nucleic acid recognition system and chemical scission system and can cleave both DNA and RNA in either form of single or double strand at any selected site, beyond the restriction of natural specifity of restriction enzymes. In addition to introducing some new chemical nuclease systems, this paper stresses on the discussion of their action modes and acting mechanisms.

Key words: chemical nucleases, cleavage in sequence specific way, acting mechanism

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