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Progress in Chemistry 1997, Vol. 9 Issue (03): 239- Previous Articles   Next Articles

• Review •

Small Molecular Chemical Libraries Generated Through Solid Phase Organic Synthesis

Li Weizhang;Liu Gang;Yun Liuhong   

  1. (Institute of Pharmacology and Toxicology, Academy of Military Sciences, Beijing 100850, China)
  • Received: Revised: Online: Published:
  • Contact: Li Weizhang
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Recent progress in solid phase supported organic synthesis of heterocyclic libraries with important physiological activity, such as 1, 4- benzodiazpines, diketopiperazines, isoquinolinones, dihydro and tetrahydroisoquinolines, 1, 4-dihydropyridines, dihydropyrimidines, hydantoins, pyrrolidines, thiazolidine-4-carboxylic acids, 4-thiazolidnones and related 4-metathiazanones, imidazoles, β-lactams and related azetidinones; important targeted libraries including β-turn mimetics library, protease and kinase inhibitor libraries such as aspartic acid protease, HIV-1 protease, zinic protease, carbonic anhydrase、tyrosine kinase, as well as estrogen receptor ligand library are reviewed.

Key words: solid phase organic synthesis, combinatorial chemistry, small molecular chemical library, heterocyclic library, targeted library

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