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Progress in Chemistry 1997, Vol. 9 Issue (03): 223-   Next Articles

• Review •

Combinatorial Chemistry, Molecular Libraries and Studying of New Drugs

Liu Gang;Yun Liuhong;Wang Jianxin   

  1. (Institute of Pharmacology and Toxicology, Academy of Military Sciences,Beijing 100850, China; Chiron Corporation, 4560 Horton Street, Emeryville, CA94608, USA)
  • Received: Revised: Online: Published:
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Combinatorial chemistry is a new strategy for discovery and optimization of lead compounds in drug design in 1990s. It makes a big difference from traditional method in which pure compounds are synthesized, purified and screened one by one. Combinatorial chemistry is a type of synthetic and screening strategy which leads to large chemical libraries and extremely accelerates the rate of finding and optimizing new lead compounds.In this paper, the essential theories, methods, development tendency, achievements of combinatorial chemistry are reviewed.

Key words: combinatorial chemistry, molecular libraries, molecular diversity, lead compounds, high throughput screening, new drug discovery

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