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Progress in Chemistry 1997, Vol. 9 Issue (01): 99- Previous Articles   

• Review •

Neutron Capture Therapy(NCT)for Cancers

Wang Xiangyun;Bao Shanglian;Song Ruixia;Zhao Yunling;Xie Jinglin;Liu Yuanfang   

  1. (Department of Technical Physics, Heavy Ion Physics Institute,Peking University, Beijing 100871, China)
  • Received: Revised: Online: Published:
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The principle of neutron capture therapy (NCT ) , its historical evolution,and the latest developments were briefly described. The successful application of NCT needs high quality epithermal neutron beams, highly selective NCT drugs, accurate dose calculation and measurements, and well conceived therapeutic planning. Two possible kinds of facilities for production of epithermal neutron beam , i. e. , nuclear reactors and particle accelerators were discussed. The requirements for epithermal neutron beam were also included. The comparative evaluation of four possible NCT varieties, BNCT ,GdNCT , LiNCT ,UNCT , and relevant tumor seeking drugs were given. The conduction of NCT research in China was finally suggested.

Key words: neutron capture therapy (NCT ), BNCT, GdNCT, L iNCT, UNCT, NCT drugs, epithermal neutron beam

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[1 ] Locher G L , Amer. J. Roentgenol. , 1936, 36, 1～ 13.
[2 ] Hatanaka H, Sweet W H, Sano K, Ellis F, Pureand Appl. Chem. , 1991, 63 (3) , 373～ 374.
[3 ] 曾骏, 王凤琴, 赵惠扬, 核科学与工程, 1994, 14 (2) , 175～ 179.
[4 ] Yanch J C, Zhou X L , Med. Phys. , 1992, 19 (3) , 709～ 721.
[5 ] Gad Shani, Lev Tsvang, Semion Rozin,in Programand Abstracts of the Sixth International Symposiumon Neutron Capture Therapy for Cancer ( ISN CT ) , Oct. 31～ Nov. 4, 1994, Kobe, Japan.p. 43.
[6 ] Ranadive G N , Rosenzweig H S, Epperly M W , Bloomer W D, Nucl. Med. Biol. , 1993, 20 (1) , 1～ 6.
[7 ] Soloway A H, Wyzlic I M , Tjarks W , Hariharan A , Burgos-Fuster M , Barth R F,in Program and Abstracts of the Sixth International Symposium on Neutron Capture Therapy for Cancer ( ISN CT ) ,Oct. 31～Nov. 4, 1994, Kobe, Japan.p. 89.
[8 ] Pinelli T , Altieri S, Fossati F, Zonta A , Cossard D, Riceventi G,ibid. ,p. 95.
[9 ] Groshev L V , Demidov A M , Pelekhov V I, Nucl. Phys. , 1960, 16 , 645～ 656.
[10 ] Greenwood R C, Reich C W , Baader H A et al. , Nucl. Phys. , 1978, A 304, 327～ 428.
[11 ] Shih J L A , Brugger R, Med. Phys. , 1992, 19 (3) , 733～ 744.
[12 ] Kalend A M , Bloomer W D, Epperly M et al. , Med. Phys. , 1991, 18, 662.
[13 ] Liu H B, Brugger R M , Shih J L A et al. , Med. Phys. , 1992, 19 (3) , 706～ 708.
[14 ] Masiakowski J T , Horton J L , Peters L J , Med. Phys. , 1992, 19, 1275～ 1284.
[15 ] Science, 1994, 265, 468～ 469.
[16 ] Science, 1994, 265, 1799.
[17 ] Brugger R M , Liu H B, Laster B H,in Advances in Neutron Capture Therapy (eds. Soloway A H et al. ) , Plenum Press, New York, 1993.
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Neutron Capture Therapy(NCT)for Cancers