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Progress in Chemistry 1994, Vol. 6 Issue (01): 26- Previous Articles   Next Articles

• Review •

Progress in Chemical Research of Monoclonal Antibodies Labeling with Radionuclides

Liu Bin   

  1. (Department of Technical Physics, Peking University, 100871)
  • Received: Revised: Online: Published:
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The monoclonal antibody (MoAb) technique has been regarded as an encouraging and promising approach which may lead to exciting advances in both diagnosis and therapy of human cancer. This paper deals with the chemical aspects of the radiolabeling of MoAb. The selection of radionuclides to be used for diagnosis purpose and therapeutic use are elucidated. Both direct labeling methods, as well as indirect methods using the bifunctional chelating agent approach are coveyed. The techniques related to the protein modification i. e. the coupling of MoAb and chelator，the improvement of T/N ratio are also included.

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