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Progress in Chemistry 1994, Vol. 6 Issue (01): 1-   Next Articles

• Review •

Chemically Modified Oligonucleotides as Antisense Inhibitor of Gene Expression

Chen Yaoquan; Wang Zhengfu; Qu Fucheng   

  1. (State Key Laboratory of Bioorganic and Natural Products Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received: Revised: Online: Published:
  • Contact: Yaoquan Chen
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This review article describes the principles and mechanisms of antisense oligonucleotides (oligos)as inhibitor of gene expression;the critieria that oligo:; must meet as therapeutic agents of human disease;the chemically-modified oligos, their properties and the level which has been achieved in research and application.

Key words: antisense oligonucleotides;inhibitor of gene expression
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