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Progress in Chemistry 2023, Vol. 35 Issue (8): 1266-1274 DOI: 10.7536/PC221213 Previous Articles   

• Review •

Home Diagnosis of Myocardial Infarction: Aptamer-Based cTnI Sensing Technology

Zhiyuan Xu1,2, Guowei Gao1,2, Yansheng Li1,2(), Qingwei Liao1,2, Jingfang Hu1,2, Xueji Zhang3   

  1. 1 Key Laboratory of Sensors, Beijing Information Science and Technology University,Beijing 100101, China
    2 Key Laboratory of Modern Measurement and Control Technology of Ministry of Education, Beijing Information Science and Technology University,Beijing 100192, China
    3 School of Biomedical Engineering, Shenzhen University,Shenzhen 518060, China
  • Received: Revised: Online: Published:
  • Contact: *e-mail: lys2019@bistu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(62101053); R&D Program of Beijing Municipal Education Commission(KM202211232004); Fundamental Research Funds for the Central Public Welfare Research Institutes(RXRC2022001); Project of Construction and Support for high-level Innovative Teams of Beijing Municipal Institutions(BPHR20220124)
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Cardiac troponin I (cTnI) is a biomarker closely associated with acute myocardial infarction (AMI) and is considered as the "gold standard" for the diagnosis of AMI. A variety of cTnI detection techniques have been developed, including antibody-based and aptamer-based detection methodology. Aptamers are short DNA or RNA sequences that can specifically bind to the target, and have been used in the development of cTnI detection platforms due to their advantages of good stability, easy synthesis and low cost. In this paper, cTnI detection methods are divided into optical detection and electrochemical detection according to the signal transduction mode. This review introduces the current research progress of aptamer-based cTnI sensing technology, describes the detection principle, performance, advantages and disadvantages of various methods, summarizes cTnI sensing technology and prospects its development in home testing, hoping to provide reference for the development of more sensitive and portable cTnI sensors.

Contents

1 Introduction

2 Optical detection

2.1 Fluorescence detection method

2.2 Surface-enhanced Raman scattering

2.3 Electrochemical luminescence method

3 Electrochemical detection

3.1 Electrochemical impedance spectrum

3.2 Differential pulse voltammetry

3.3 Square wave voltammetry

4 Conclusion and outlook

Key words: cardiac troponin I, aptamer, home testing, electrochemistry
Fig.1 Schematic representation of aptamer sensor for cTnI detection based on GO platform[26]
Fig.2 Schematic diagram of cTnI measurement based on aptamer using SERRS active particles on paper platform[36]
Fig.3 Schematic diagram of ECL sensor for detecting cTnI[41]
Fig.4 EIS aptamer sensor detection process[59]
Fig.5 Detection principle of electrochemical dual aptamer biosensor combined with NTH[61]
Fig.6 cTnI detection schematic diagram[70]
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